Risk of skin and soft tissue infections (including shingles) in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register

Abstract

A significantly increased risk of shingles was observed in the anti-TNF-treated cohort. The risk of SSSI tended towards being greater with anti-TNF treatment but was not statistically significant. As with any observational dataset cause and effect cannot be established with certainty as residual confounding may remain. This finding would support the evaluation of zoster vaccination in this population.

References

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	Year	Citations
Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis M.L.L. Prevoo, Martin A. van't Hof, H. H. Kuper, Arthritis & Rheumatism	1995	6.1K
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults Michael N. Oxman, Myron J. Levin, Gary R. Johnson, New England Journal of Medicine	2005	2.4K
Frequency of infection in patients with rheumatoid arthritis compared with controls: A population‐based study Michele F. Doran, Cynthia S. Crowson, Gregory R. Pond, Arthritis & Rheumatism	2002	1.2K
Vaccinia (Smallpox) Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001 PsycEXTRA Dataset	2001	1K
Rates of serious infection, including site‐specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti–tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register William G Dixon, K. Watson, Mark Lunt, Arthritis & Rheumatism	2006	752
Infections in patients with rheumatoid arthritis treated with biologic agents Joachim Listing, Anja Strangfeld, S. Kary, Arthritis & Rheumatism	2005	684
Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly James Galloway, Kimme L Hyrich, Louise Mercer, Lara D. Veeken	2010	656
Risk of Herpes Zoster in Patients With Rheumatoid Arthritis Treated With Anti–TNF-α Agents Anja Strangfeld JAMA	2009	538
Using Inverse Probability-Weighted Estimators in Comparative Effectiveness Analyses With Observational Databases Lesley H. Curtis, Bradley G. Hammill, Eric L. Eisenstein, Medical Care EngineeringTreatment EffectQuasi-experimentObservational DatabasesInverse Probability-weighted Estimators	2007	501
STANFORD HEALTH ASSESSMENT QUESTIONNAIRE MODIFIED TO ASSESS DISABILITY IN BRITISH PATIENTS WITH RHEUMATOID ARTHRITIS John Kirwan, J S Reeback Lara D. Veeken Quality Of LifeDisabilityHealth PsychologyFunctional ChangesRheumatoid Disorder	1986	483

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