Identification of electromagnetic field parameters assuring the cancer destruction during hyperthermia treatment

Abstract

Electromagnetic field induced by two external electrodes and temperature field resulting from electrode action in the domain of biological tissue being a composition of healthy region and a tumour is considered. To warrant the optimum conditions of tumour destruction, the magnetic nanoparticles are embedded in this region. It is assumed that the temperature which assures an effect of destruction should be higher than 42°C. In this article, the problems relating to the electrodes’ electric potential identification and the simultaneous identification of potential and number of nanoparticles introduced to the tumour region are discussed. Additional information necessary to solve the task results from the postulated temperature inside the tumour region assuring its destruction. The problem has been solved using both the gradient method and evolutionary algorithm. The boundary element method is applied to solve the coupled problem connected with the heating of biological tissues.