Fluorescence Detection of Malignant Liver Tumors using 5‐Aminolevulinic Acid‐Mediated Photodynamic Diagnosis: Principles, Technique, and Clinical Experience

Abstract

With the detection of malignant liver tumors, residual tumor and bile leakage at the cut surface of the remnant liver were improved by PDD with 5-ALA. This procedure may provide greater sensitivity than the conventional procedure. Furthermore, 5-ALA-mediated PDD can ensure histological clearance regardless of the resection margin and preserve as much liver parenchyma as possible in patients with impaired liver function.