European Journal of Endocrinology · 1969 · 14 citations · 0 references
MedicineEndocrinologyPhysiologyReproductive BiologyReproductive EndocrinologyReproductive PhysiologyOvarian FunctionOvarian PhysiologyReproductive Tract PhysiologyUterine PathologyCell LysisCellular ProliferationEndometrial Proliferative ChangesFibrinolytic RegulationSlide TechniqueSurface EpitheliumUterine PhysiologyUterus Function
ABSTRACT The influence of oestrogen, gestagen and gonadotrophins on the fibrinolytic activity of the juvenile rat uterus and vagina was studied histochemically using the fibrin slide technique. Tissue specimens were obtained from animals killed 48 hours after termination of hormone treatment. Oestradiol enhanced tissue fibrinolysis and produced areas of intense lysis along the endometrial surface epithelium and the vaginal mucosa. Progesterone had no enhancing effect on tissue fibrinolysis. Chorionic gonadotrophin and serum gonadotrophin had little or no enhancing effect on fibrinolysis in the uterus, though there was tremendous hypertrophy. In the vagina the increased cellular proliferation and desquamation was followed by an increase in fibrinolytic activity of the mucosa. In all specimens fibrinolysis was caused by an activator of plasminogen.