Contribution of genetic polymorphisms of stromal cell–derived factor‐1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

Abstract

SDF-1-3'A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph-node metastasis of oral cancer disease in Taiwanese.