Direct analysis of samples under ambient condition by high‐voltage‐assisted laser desorption ionization mass spectrometry in both positive and negative ion mode

Abstract

HALDI-MS can directly analyze a variety of liquid samples including proteins, ODNs, pharmaceuticals and biological fluids in both positive and negative ion mode without the use of an organic matrix. This technique may be further developed into a useful tool for rapid analysis in many different fields such as pharmaceutical, food, and biological sciences.