Publication | Closed Access
Differential Radioprotection of Euoxic and Hypoxic Mouse Mammary Tumors by a Thiophosphate Compound
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1974
Year
PathologyTumor BiologyDecreased ProtectionOxygenated PortionRadiation MedicineCancer Cell BiologyRadiopharmaceutical TherapyDifferential RadioprotectionRadioprotective Drug S-2-Radiation OncologyNuclear MedicineCancer ResearchRadiation TherapyMedicineTumor TargetingCancer TreatmentPharmacologyMalignant DiseaseTumor MicroenvironmentEndocrine-related CancerThiophosphate CompoundBreast CancerOncology
The radioprotective drug S-2-(3-aminopropylamino) ethyl phosphorothioate (WR2721) was evaluated in the EMT-6 mouse mammary tumor. Under euoxic conditions (DMF approximately 2), the drug protected the oxygenated portion of the tumor but not chronically hypoxic cells. Acutely hypoxic cells were protected to a slight degree. Since WR2721 has been shown to protect normal tissues with a DMF of 2–3, it is likely that decreased protection of anoxic tumor cells will be clinically useful.