Insulin-like growth factor-I (IGF-I) Stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate

Abstract

Following intestinal damage of methotrexate, IGF-I primarily induced growth of the distal small intestine. The ineffectiveness of concurrently administered IGF-I may have represented an IGF-I induced recruitment of proliferating epithelial cells to the anti-proliferative effects of methotrexate.