Genetic variants in<i>CDC42</i>and<i>NXPH1</i>as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Abstract

Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with IBS-D and IBS-C, respectively, in two independent cohorts. Further studies are warranted to validate our findings and to determine the mechanisms underlying IBS pathophysiology.