European Journal of Organic Chemistry · 2015 · 17 citations · 26 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryCatalytic MaterialsCatalytic MechanismsOrganic SynthesisCopper-catalyzed CouplingFunctionalizationHeterocycle FunctionalizationIsoquinoline ChemistryTransition-metal-catalyzed Functionalization
Abstract A facile, one‐step, direct functionalization of the C1 and N positions of tetrahydroisoquinolines was developed. Unprotected tetrahydroisoquinolines, indoles, and benzaldehydes could be used as starting materials. The different substituted indoles and benzaldehydes were investigated in detail and the scope proved to be broad.
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