Proceedings of the National Academy of Sciences · 1969 · 12 citations · 7 references
PharmacyBiochemistryChemistryNucleic Acid BiochemistryNucleic Acid ChemistryRadiobiologyBiological Effects Of RadiationDna ChemistryDna DamageRadiation BiologyRadiation ChemistryRadical ReactionsIonizing Radiation-induced Dna BreaksOxidative Dna Base ModificationsRadiation Chemistry Of Biological MoleculesRadiation-induced Dna DamageRadiation-induced Free RadicalsRadiation-induced Reaction Mechanisms
Electron spin resonance spectroscopy has been used to study transformation of radicals in DNA and a number of its constituents. It was found that in all the bases irradiated at 77 degrees K, hydrogen-addition radicals were formed on warming. The following mechanism of radical transformation has been proposed: damaged species, probably ion-radicals, release hydrogen atoms on warming, which then add to the undamaged bases, preferentially thymine. Thymine need not be the place of the primary damage.
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