17β‐Estradiol‐Associated Stealth‐Liposomal Delivery of Anticancer Gene to Breast Cancer Cells

Abstract

Killing by stealth: The highly specific mutual affinity of estrogen receptor and 17β-estradiol (ES) allows apoptotic genes to be targeted at primary human breast adenocarcinoma cells through the use of stealth liposomes. Cells are transfected with a cationic lipoplex containing a targeting lipid (see picture; DPPE=1,2-dipalmitoyl-Sn-glycero-phosphatidylethanolamine, PEG=poly(ethylene glycol)).