A novel polymorphism in the PAI-1 gene promoter enhances gene expression. A novel pro-thrombotic risk factor?

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.

Per Eriksson, Bengt Kallin, Peter Båvenholm et al. · Proceedings of the National Academy of Sciences · 1995 · 744 citations

Medicine, Genetics, Molecular Genetics +14

The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells

Sally J. Dawson, B. Wiman, Anders Hamsten et al. · Journal of Biological Chemistry · 1993 · 569 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Venous thrombosis risk associated with plasma hypofibrinolysis is explained by elevated plasma levels of TAFI and PAI-1

Mirjam E. Meltzer, Ton Lisman, Philip G. de Groot et al. · Blood · 2010 · 363 citations · Full text

Medicine, Hematology, Hemostasis +10

PAI‐1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs

Günay Balta, Çiğdem Altay, Aytemiz Gürgey · American Journal of Hematology · 2002 · 95 citations

Medicine, Genetics, Hematology +12

Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis. A meta-analysis.

Argirios Ε. Tsantes, Georgios K. Nikolopoulos, Pantelis G. Bagos et al. · PubMed · 2007 · 94 citations

Medicine, Genetics, Molecular Genetics +13