Lupus erythematosus panniculitis (lupus profundus): Clinical, histopathological, and molecular analysis of nine cases

Abstract

Our study shows that the most useful histopathologic criteria for distinguishing LEP from SPTCL are the presence of involvement of the epidermis, lymphoid follicles with reactive germinal centers, mixed cell infiltrate with prominent plasma cells, clusters of B lymphocytes, and polyclonal TCR-gamma gene rearrangement.