The first total synthesis of (+)-(Z)-laureatin

A synthetic method for formyl→ethynyl conversion (RCHO→RCCH or RCCR′)

E. J. Corey, P.L. Fuchs · Tetrahedron Letters · 1972 · 1.6K citations

An Asymmetric Aldol−Ring-Closing Metathesis Strategy for the Enantioselective Construction of Oxygen Heterocycles:  An Efficient Approach to the Enantioselective Synthesis of (+)-Laurencin

Michael T. Crimmins, Allison L. Choy · Journal of the American Chemical Society · 1999 · 157 citations

Bioorganic Chemistry, Engineering, Organic Chemistry +16

Synthesis of Medium Ring Ethers. 5. The Synthesis of (+)-Laurencin

Jonathan W. Burton, J. Stephen Clark, Sam Derrer et al. · Journal of the American Chemical Society · 1997 · 131 citations

Diversity Oriented Synthesis, Derivatives, Medium Ring Ethers +13

Palladium-Catalyzed Stereoselective Hydrogenolysis of Conjugated 1,1-Dibromo-1-alkenes to (<i>Z</i>)-1-Bromo-1-alkenes. An Application to Stepwise and One-Pot Synthesis of Enediynes and Dienynes

Jun’ichi Uenishi, Reiko Kawahama, Osamu Yonemitsu et al. · The Journal of Organic Chemistry · 1996 · 126 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +13

Total Synthesis of (+)-Laurencin. Use of Acetal-Vinyl Sulfide Cyclizations for Forming Highly Functionalized Eight-Membered Cyclic Ethers

Matthias Bratz, William H. Bullock, Larry E. Overman et al. · Journal of the American Chemical Society · 1995 · 118 citations

Chemical Engineering, Engineering, Natural Sciences +12