Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling

Global cancer statistics

Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Medicine, Oncology, Cancer Epidemiology +15

Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial.

Howard A. Burris, Malcolm J. Moore, John Sahl Andersen et al. · Journal of Clinical Oncology · 1997 · 5.9K citations

Medicine, Oncology, Pharmacotherapy +16

Decreased Accessibility and Lack of Activation of ErbB2 in JIMT-1, a Herceptin-Resistant, MUC4-Expressing Breast Cancer Cell Line

Péter Nagy, Elza Friedländer, Minna Tanner et al. · Cancer Research · 2005 · 513 citations · Full text

Medicine, Cancer Biology, Molecular Biology +14

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism.

K. Kaplan, Jason R. Swedlow, David O. Morgan et al. · Genes & Development · 1995 · 318 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis

Shishir Shishodia, Bharat B. Aggarwal · Journal of Biological Chemistry · 2004 · 256 citations · Full text

Life Sciences, Cell Biology, Pharmacology +17