Total Synthesis of (−)‐Pestalotiopsin A

Abstract

A big “+”: The total synthesis of (−)-pestalotiopsin A has been achieved, thereby establishing the absolute stereochemistry of natural (+)-pestalotiopsin A (see scheme). The synthesis features a [2+2] cycloaddition, an aldol reaction, and an intramolecular Nozaki–Hiyama–Kishi reaction to construct the (E)-cyclononene ring. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z800253_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.