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THE ROLE OF THE VITAMINES OF THE BCOMPLEX IN ESTROGEN METABOLISM
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1944
Year
NutritionFertilityComparative EndocrinologyGynecologyFemale Reproductive FunctionReproductive BiologyReproductive EndocrinologyVaginal EstrusFemale InfertilityReproductive MedicinePublic HealthSteroid MetabolismAnimal PhysiologyEndocrine MechanismHormonal ReceptorAromataseMetabolomicsEndocrinologyPharmacologyOvarian HormoneRat LiverVaginal CornificationAnimal SciencePhysiologyUterine ReceptivityThe VitaminesMetabolismMedicineEndocrine Research
BISKIND AND Biskind (1942) have demonstrated that vaginal cornification does not occur in castrated female rats, fed a normal diet, in which estrone pellets have been implanted intrasplenically. This finding was interpreted as being due to the inactivation of estrone by the liver. However, when the animals were subsequently fed a Bcomplex deficient diet, most of them displayed vaginal estrus. Supplementation of the diet with yeast returned the animals to the anestrous state. We have previously reported (Segaloff, 1943) the inactivation by the rat liver of estrone and -αestradiol intrasplenically injected. In the near future a similar report will be made for diethylstilbestrol. The rats used in this study were all females of the Sprague-Dawley strain purchased from a local dealer. The basal colony diet was “Rockland Farms” rat chow upon which all animals had been maintained before being placed on the experimental diets. All rats were spayed prior to the shift to experimental diets.