Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine

Abstract

The present study demonstrates that (i) apoptosis is involved in the hypertonicity-induced cell death in MDCK cells; (ii) caspase-3, -8, and -9 may contribute to the apoptosis; and (iii) betaine has protective effect on the hypertonicity-induced apoptosis.