Mannose‐Functionalized Mesoporous Silica Nanoparticles for Efficient Two‐Photon Photodynamic Therapy of Solid Tumors

Abstract

Zap 'em! Multifunctionalized mesoporous silica nanoparticles induce significant reduction of tumor size upon two-photon excitation in the near-infrared region while being nontoxic under daylight illumination. These nanoparticles were further tested for in vivo two-photon photodynamic therapy (TPE-PDT). A 70 % regression of tumor size after a single treatment was observed in athymic mice bearing tumor xenografts. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.