Effect of Ozone and Cigarette Smoke on Lung Function

Abstract

There was essentially no change in lung function produced by noncontrolled inhalation of one cigarette. In contrast, of 11 volunteers inhaling from 1 to 3 ppm O/sub 3/, 6 could not continue for 30-min test (cough, shortness of breath, headache). Functional changes included: -16.5% VC, -20% FEV/sub 1.0/, -10.5% MEF, -12% MBC, +21.4% D/sub LCO/, -8.1% CO uptake, +12.6% resting ventilation, -8.3% alveolar CO/sub 2/, and -9.9% mixed expiratory CO/sub 2/. There was marked individual variation.