Effect of High‐Dose Vitamin C on the Steady‐State Pharmacokinetics of the Protease Inhibitor Indinavir in Healthy Volunteers

Abstract

Concomitant administration of high doses of vitamin C can reduce steady-state indinavir plasma concentrations. Subtherapeutic concentrations of antiretroviral agents have been associated with viral resistance and regimen failure, but the clinical significance of our findings remains to be established.