Concepedia

Nonrestricted Differential Intoxication of Cells by Pertussis Toxin

Ali el Bayâ, Kerstin E. Brückener, M. Alexander Schmidt

Infection and Immunity · 1999 · 22 citations · 8 references

DOIFull text

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Concepts

Abstract

After uptake and retrograde transport pertussis toxin acts by ADP-ribosylating alpha-Gi proteins. We show that uptake via many different receptor proteins followed by retrograde transport and intoxication is not restricted to a particular cell type. The efficiency of cellular intoxication, however, was found to be cell type dependent.

References

8

Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect.

Kirsten Sandvig, Kristian Prydz, Steen H. Hansen et al. · The Journal of Cell Biology · 1991 · 151 citations · Full text

, , +15

Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action

Palmer A. Orlandi, Patricia K. Curran, Peter H. Fishman · Journal of Biological Chemistry · 1993 · 124 citations · Full text

, , +16

Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein.

Michael J. Brennan, Jim David, J G Kenimer et al. · Journal of Biological Chemistry · 1988 · 113 citations · Full text

, , +15

Entry of cholera toxin into polarized human intestinal epithelial cells. Identification of an early brefeldin A sensitive event required for A1-peptide generation.

Wayne I. Lencer, Joanna Almeida, S Moe et al. · Journal of Clinical Investigation · 1993 · 96 citations · Full text

, , +17

Endocytosis and retrograde transport of pertussis toxin to the Golgi complex as a prerequisite for cellular intoxication.

el Bayâ A, Ruth Linnemann, von Olleschik-Elbheim L et al. · PubMed · 1997 · 56 citations

, , +14