Concepedia

The fusion of <i>TEL</i> and <i>ABL</i> in human acute lymphoblastic leukaemia is a rare event

Johannes W.G. Janssen, Susan A. Ridge, Panos Papadopoulos, Finbarr E. Cotter, Wolf‐Dieter Ludwig, Christa Fonatsch, Harald Rieder, Wolfram Ostertag, Claus R. Bartram, Leanne M. Wiedemann

British Journal of Haematology · 1995 · 45 citations · 10 references

DOI

Concepts

Abstract

We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.

References

10

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

Todd R. Golub, George F. Barker, Michael Lovett et al. · Cell · 1994 · 1.2K citations

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The novel activation of ABL by fusion to an ets-related gene, TEL.

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