Granulosa Cell Tumor–like Variant of Endometrioid Carcinoma of the Ovary Exhibiting Nuclear Clearing With Biotin Activity: A Subtype Showing Close Macroscopic, Cytologic, and Histologic Similarity to Adult Granulosa Cell Tumor

Abstract

Because the granulosa cell tumor-like variant is pathologically similar to granulosa cell tumor, showing only some dissimilarities to the latter, it can easily be misdiagnosed if the possibility of this variant is not kept in mind. Identification of the typical endometrioid histologic features or related lesions or immunohistochemistry may lead to a proper diagnosis. The observation of nuclear clearing with biotin activity in nonmorular nests suggests that this tumor has endometrioid epithelial characteristics.