Baroceptor and Sympathetic Activity in Experimental Renal Hypertension in the Dog

Abstract

Response to tetraethylammonium chloride was studied in normal and renal hypertensive dogs in which the carotid sinus was isolated and intrasinusal pressure was maintained by a pump. Normal, chronic, and acute renal hypertensive animals differed in their response at different intrasinusal pressure levels and indicated resetting of the baroceptors in the chronic hypertensive phase but not in the acute phase. This resetting may play a role in the maintenance of chronic renal hypertension.