Formation of a Dinuclear Copper(I) Complex from the <i>Clostridium</i>‐Derived Antibiotic Closthioamide

Abstract

A metal chelator from the oxygen-free world: Multiple lines of experimental evidence show that closthioamide, the first antibiotic from a strictly anaerobic bacterium (Clostridium), is a selective copper(I) chelator. The geometry of the polythioamide complex, in which two copper ions in a trigonal-planar coordination stabilize the pitch of a helix-like arrangement, is unprecedented for natural products. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.