Unusual Ester‐Directed Regiochemical Control in <i>endo</i>‐Selective Asymmetric 1,3‐Dipolar Cycloadditions of Azomethine Ylides with β‐Sulfonyl Acrylates

Abstract

Ester-controlled regioselectivity! A highly efficient, asymmetric 1,3-dipolar cycloaddition of azomethine ylides with unsymmetrically 1,2-diactivated sulfonylacrylates has been developed, accompanied by an unusual regioselectivity that is controlled by the ester group rather than the sulfonyl group (see scheme). Theoretical calculations revealed a stepwise mechanism and rationalized the unusual ester-directed regioselectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.