Congenital Kaposiform Hemangioendothelioma with Kasabach–Merritt Phenomenon Successfully Treated with Low‐Dose Radiation Therapy

Abstract

Kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon is a life-threatening vasculopathy. The current mainstay treatment for KHEs is corticosteroids and chemotherapy, but these medications do not work for all patients and carry significant side effects. We report a neonate with a large congenital KHE who responded extremely well to low-dose radiation therapy.