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Synthesis and Urease Enzyme Inhibitory Effects of Some Dicoumarols

DOIFull Paper Access

25

Citations

16

References

2004

Year

Khalid Mohammed Khan, Sajid Iqbal, Muhammad Arif Lodhi, Ghulam M. Maharvi, Shahnaz Perveen, M. Iqbal Choudhary, Atta‐ur Rahman, Zahid H. Chohan, Claudiu T. Supuran
Journal of Enzyme Inhibition and Medicinal Chemistry

Abstract

Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM.

References

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