The Frequency of a Common Mutation of the Methionine Synthase Gene in the Australian Population and its Relation to Smoking and Coronary Artery Disease

Abstract

We conclude that the methionine synthase 2756A-->G mutation is common, with homozygosity occurring in approximately 4% of white Australians, and that it has an interactive effect with life-time smoking dose to increase the severity of CAD. Smokers who are also GG homozygotes have additionally elevated CAD risk.