Cytokine pattern determines the progression of experimental periodontal disease induced by <i>Actinobacillus actinomycetemcomitans</i> through the modulation of MMPs, RANKL, and their physiological inhibitors

Abstract

It is possible that the pattern of cytokines produced in periodontal tissues determines the progression and the severity of experimental periodontal disease, controlling the breakdown of soft and bone tissues through the balance between MMPs/TIMP and RANKL/OPG expression in gingival tissues.