Publication | Open Access
Alkylation of manganese(ii) tetraphenylporphyrin by a synthetic antimalarial trioxane
10
Citations
36
References
2003
Year
Inorganic ChemistryMedicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryHeterocyclicNatural SciencesMedicineAntimalarial ActivityBioorganometallic ChemistryOrganic ChemistryHeme Model MniitppChemistryHemiperketal 2Heterocycle ChemistryPharmacologySynthetic Antimalarial TrioxaneSynthetic ChemistryDrug Discovery
The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
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