Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1

Abstract

While a wealth of data has uncovered distinct microRNA (miR) expression alterations in hypertrophic and ischaemic/ reperfused (I/R) hearts, little is known about miR regulation and response to ischaemic preconditioning (IPC).