Synthesis and biological activity of a new class of sulfone linked bis(heterocycles)

Abstract

Novel sulfone linked bis(heterocycles) having two different heterocyclic rings viz., oxazoline / thiazoline in combination with pyrrole are prepared from E-aroylethenesulfonylacetic acid methyl ester exploiting ester and olefin functionalities. The compounds having pyrrole and thiazoline rings exhibited greater antimicrobial activity.