Effects of the Type 2 Diabetes-Associated<i>PPARG</i>P12A Polymorphism on Progression to Diabetes and Response to Troglitazone

Abstract

The proline allele at PPARG P12A increases risk for diabetes in persons with impaired glucose tolerance, an effect modified by body mass index. In addition, PPARG P12A has little or no effect on the beneficial response to troglitazone.