Cytokine Blockade Attenuates Sympathoexcitation in Heart Failure: Cross-Talk Between nNOS, AT-1R and Cytokines in the Hypothalamic Paraventricular Nucleus

Abstract

PTX decreased both peripheral and central cytokine expression, alleviated nitric oxide dysregulation, and inhibited the formation of peroxynitrite in the PVN resulting in decreased sympathoexcitation in CHF rats.