Asymmetric Total Synthesis of Solandelactone E: Stereocontrolled Synthesis of the 2‐ene‐1,4‐diol Core through a Lithiation–Borylation–Allylation Sequence

Abstract

A highly stereoselective, 13-step synthesis of solandelactone E is reported which employs the lithiation–borylation–allylation sequence as the key step (see scheme). This synthetic method solves the problem of poor stereocontrol at C11 that had dogged many previous syntheses of this class of molecules. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.