2008 · 10 citations · 2 references
Life SciencesBioinformaticsComplex SystemsNetwork BiologyProtein-protein InteractionsCommunity DetectionCommunity StructureInteraction NetworksNetwork TheoryProtein-protein Interaction NetworksScale-free NetworksClique AlgorithmsCliquesDominating SetsFixed-parameter TractabilityNetwork Topology AnalysisProtein Interaction Network TopologyScale-free Network ModelingScale-free Topology
Scale-free networks are believed to closely model most real-world networks. An interesting property of such networks is the existence of so-called hub and community structures. In this paper, we model hubs as high-degree nodes and communities as quasi cliques. We propose a new problem formulation called the ¿-list dominating set and show how this single problem is suited to model both the structures in real-world networks better than traditional problems like vertex cover and clique. Additionally, we provide a fixed-parameter tractable algorithm to this detect these structures and show experimental results on protein-protein interaction networks.
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Scale-Free Behavior in Protein Domain Networks
Stefan Wuchty · Molecular Biology and Evolution · 2001 · 260 citations