Open‐State Unblock Characterizes Acute Inhibition of <i>I</i>_Ks Potassium Current by Amiodarone in Guinea Pig Ventricular Myocytes

Abstract

We propose that amiodarone acutely blocks native IKs with characteristics associated with open channel unblock, and that the protein kinase A-mediated phosphorylation of channel proteins only minimally affects the amiodarone block.