Cohen syndrome with neutropenia-induced periodontitis managed with granulocyte colony-stimulating factor (G-CSF): case reports.

Abstract

Cohen syndrome was first reported in 1973 in two siblings and one sporadic case. ~ Features mentioned in the original report included obesity/hypotonia, mental retardation, narrow hands and feet, ocular abnormalities, and characteristic facies consisting of maxillary hypoplasia, mild micrognathia, short philtrum, open mouth, prominent central incisors, and downslanting palpebral fissures. Although more than 100 cases have now been reported in the medical literature, 3-21 only two previous reports have appeared in the dental literature. The first described a young girl with Cohen syndrome showing typical craniofacial features such as short philtrum and prominent incisors but no periodontal involvement. 14 The second was a controlled study which demonstrated significant periodontal disease in a group of 15 Cohen syndrome patients with neutropenia, but craniofacial features were not described. 3