Low-Dose Tissue Plasminogen Activator for Calciphylaxis

Abstract

A).Theulcerationprogressedinspiteofmul-tipletreatmentselsewherethatincludedintensivewoundcarewithwet-to-drydressings,topicalbecaplermin,sur-gical debridement, and Unna boot dressings. A skin bi-opsyspecimendemonstratedintravascularandextravas-cular calcification with pannicular necrosis and fibrinthrombi in dermal blood vessels consistent with calci-phylaxis (