Alternative splicing alterations of <scp>Ca</scp>²⁺ handling genes are associated with <scp>Ca</scp>²⁺ signal dysregulation in myotonic dystrophy type 1 (<scp>DM</scp>1) and type 2 (<scp>DM</scp>2) myotubes

Abstract

The aberrant splicing of RYR1, SERCA1 and Cav 1.1 may alter intracellular Ca(2+) signalling in DM1 and DM2 myotubes. The differing dysregulation of intracellular Ca(2+) handling in DM1 and DM2 may explain their distinct sarcolemmal hyperexcitabilities.