Publication | Closed Access
INFLUENCE OF TESTOSTERONE ON THE SECRETION OF THYROTROPHIN IN THE RAT
16
Citations
0
References
1965
Year
Pituitary GlandAbstract CastrationEndocrine ResearchEndocrine MechanismLow Pituitary Tsh-contentsPhysiologyThyroid DisordersReproductive BiologyPublic HealthEndocrinologyMedicineThyroid HormoneThyroid PhysiologyReproductive HormoneReproductive Endocrinology
ABSTRACT Castration of male rats decreases both pituitary and serum TSH-levels. Administration of testosterone propionate increases serum TSH-levels in castrated males, but its effect on pituitary TSH-content appears to be complex: whereas treatment with physiological amounts of testosterone prevents the decrease induced by castration, administration of high doses of testosterone results in low pituitary TSH-contents not unlike those seen in untreated castrated rats. Testosterone administered to thyroxine-maintained thyroidectomized rats had the same effects as mentioned above, but if thyroxine treatment was omitted, no effect of testosterone on pituitary and serum TSH-levels could be observed. It is thought that testosterone interferes with the effect of thyroid hormone on the secretion of TSH.