Prognostic value of MIB-1, p53, epidermal growth factor receptor, and INI1 in childhood chordomas

Abstract

A subset of pediatric chordomas with atypical histomorphologic features needs to be identified, as they behave in an aggressive manner and require adjuvant therapy. Pediatric chordomas more frequently show p53 expression, INI1 loss, and higher MIB-1 LI as compared with adults, whereas EGFR expression is common to both.