AIDS‐Associated<i>Cryptococcus neoformans</i>and<i>Penicillium marneffei</i>Coinfection: A Therapeutic Dilemma in Resource‐Limited Settings

Abstract

AIDS&#x2010;associated Cryptococcus neoformans and Penicillium marneffei coinfection has not been adequately studied and poses unique therapeutic challenges in resource&#x2010;limited settings. Itraconazole poorly penetrates the central nervous system, whereas fluconazole has poor activity against P. marneffei. We prospectively report management of 1 patient and retrospectively review 7 coinfection cases from Vietnam.