Fine‐Tunable Organocatalysts Bearing Multiple Hydrogen‐Bonding Donors for Construction of Adjacent Quaternary and Tertiary Stereocenters via a Michael Reaction

Abstract

Elaborately designed fine-tunable bifunctional amine–thiourea organocatalysts, relying on multiple hydrogen-bonding donors, show excellent activity, diastereoselectivity, enantioselectivity and structural potential in the asymmetric Michael addition of α-substituted β-ketoesters to nitroolefins. Multiple hydrogen-bonding donors play a significant role in accelerating reactions, improving yields, diastereoselectivities and enantioselectivities. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2111/2008/z801420_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.