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meta-Bromination of phenols in superacids
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1980
Year
EngineeringBiochemistryO-protonated SubstrateSecondary MetaboliteOrganic ChemistryCorresponding Meta-bromo-substituted Compounds2,6-Dialkylated PhenolsHalogenationBiomolecular Engineering
In SbF5–HF, para-alkylated or 2,6-dialkylated phenols (and their ethers) react with bromine to give the corresponding meta-bromo-substituted compounds; the mechanism implies bromination of the O-protonated substrate.