Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

Abstract

When using the RIFLE criteria, colistin-related nephrotoxicity is observed in a high percentage of patients. Cmin levels are predictive of AKI. Patients who receive intravenous colistin should be closely monitored and Cmin might be a new useful tool to predict AKI.