Angiotensin II Induces Leukocyte–Endothelial Cell Interactions In Vivo Via AT ₁ and AT ₂ Receptor–Mediated P-Selectin Upregulation

Abstract

-Ang II induces significant leukocyte rolling, adhesion, and emigration, which may contribute not only to hypertension but also to the onset and progression of the vascular damage associated with disease states in which plasma levels of this peptide are elevated.